Objective: To prepare and characterize the solid lipid nanoparticles containing norcantharidin.
Methods: Entrapment efficiency was studied to choose the best method of preparing norcantharidin solid lipid nanoparticles. The physico-chemical properties of norcantharidin solid lipid nanoparticles were investigated.
Results: The entrapment efficiency of norcantharidin in solid lipid nanoparticles was 54.6%, the average particle diameter was 190 nm, and it was stable at 4 degrees C for 3 months.
Conclusion: Solid lipid nanoparticles of norcantharidin prepared has high entrapment efficiency and good stability.