[Studies on reaction and antibacterial activity of 1-aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazole with several electrophilic reagents]

Yao Xue Xue Bao. 1991;26(11):809-14.
[Article in Chinese]

Abstract

Upon treatment of 1-aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazoles (1) with excess acetic acid, acetic anhydride, acetyl chloride, benzoyl chloride, formamide, etc., fourteen new derivatives of 1 were obtained in good yields, such as, 1-H-4-ethoxycarbonyl-5-arylamino-1,2,3-triazoles (2b-d), 1-RCO-4-ethoxycarbonyl-5-arylamino-1,2,3-triazoles (3a-d), 1-aryl-4-ethoxycarbonyl-5-acetylamino-1,2,3-triazoles (4a-d) and 1-formoyl-4-ethoxycarbonyl-5-p-nitrophenylamino-1,2,3-triazole (5a), 1-benzoyl-4-ethoxycarbonyl-5-p-nitrophenylamino-1,2,3-triazoles (5b), 1-p-chlorobenzoyl-4-ethoxycarbonyl-5-p-nitrophenylamino-1,2,3-triazoles (5c). Some of them were rearrangement products. Structures of all heterocyclic compounds were identified by elemental analyses, IR, 1HNMR and MS. Inhibiting effects of some compounds on B. substilis, E. coli, E. aerogenes and S. aureus were also screened.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Escherichia coli / drug effects
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Triazoles / chemical synthesis
  • Triazoles / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Triazoles