Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella species

Am J Infect Control. 2008 Feb;36(1):70-3. doi: 10.1016/j.ajic.2007.01.012.

Abstract

In pediatric bloodstream infections with fluoroquinolone (FQ)-resistant Escherichia coli and Klebsielia species, we noted an association between FQ resistance and extended-spectrum beta-lactamase (ESBL) production (OR, 12; 95% CI: 2.28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / microbiology*
  • Case-Control Studies
  • Child
  • Drug Resistance, Bacterial*
  • Escherichia coli / drug effects*
  • Escherichia coli / isolation & purification
  • Female
  • Fluoroquinolones / pharmacology*
  • Humans
  • Klebsiella / drug effects*
  • Klebsiella / isolation & purification
  • Male
  • Risk Factors
  • beta-Lactamases / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • beta-Lactamases