Abstract
A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Cattle
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Cell Line
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HIV Integrase / metabolism*
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HIV Integrase Inhibitors / chemical synthesis*
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HIV Integrase Inhibitors / chemistry
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HIV Integrase Inhibitors / pharmacology*
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Humans
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Phenylpropionates / chemical synthesis*
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Phenylpropionates / chemistry
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Phenylpropionates / pharmacology*
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Succinates / chemical synthesis*
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Succinates / chemistry
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Succinates / pharmacology*
Substances
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HIV Integrase Inhibitors
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Phenylpropionates
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Succinates
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fukiic acid
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HIV Integrase
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p31 integrase protein, Human immunodeficiency virus 1