Abstract
Seven new beta-carboline-based metabolites, designated as eudistomins Y1-Y7 ( 1- 7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the beta-carboline nucleus at C-1. Eudistomins Y 1-Y 7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Bacillus subtilis / drug effects
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Carbolines / chemistry
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Carbolines / isolation & purification*
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Carbolines / pharmacology
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Gram-Positive Bacteria / drug effects*
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Korea
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus epidermidis / drug effects
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Urochordata / chemistry*
Substances
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Alkaloids
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Anti-Bacterial Agents
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Carbolines
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eudistomin Y6