Abstract
Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients.
Publication types
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Editorial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Inhalation
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Anti-Infective Agents / pharmacology*
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Biofilms / drug effects
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Chemotaxis / drug effects
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Cystic Fibrosis / complications
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Cystic Fibrosis / drug therapy*
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Flagella / drug effects*
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Humans
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Pseudomonas Infections / complications
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Pseudomonas Infections / prevention & control
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / physiology
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Respiratory Tract Infections / complications
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Respiratory Tract Infections / prevention & control
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Saline Solution, Hypertonic / pharmacology*
Substances
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Anti-Infective Agents
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Saline Solution, Hypertonic