Multiple Endocrine Neoplasia type 1

Grzegorz Piecha; Jerzy Chudek; Andrzej Wiecek

doi:10.1016/j.ejim.2007.08.004

Multiple Endocrine Neoplasia type 1

Eur J Intern Med. 2008 Mar;19(2):99-103. doi: 10.1016/j.ejim.2007.08.004. Epub 2007 Nov 7.

Authors

Grzegorz Piecha¹, Jerzy Chudek, Andrzej Wiecek

Affiliation

¹ Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, ul. Francuska 20/24, 40-027 Katowice, Poland.

PMID: 18249304
DOI: 10.1016/j.ejim.2007.08.004

Abstract

The co-occurrence of parathyroid hyperplasia with pancreatic endocrine tumours and/or pituitary adenoma is classified as Multiple Endocrine Neoplasia type 1 (MEN-1) and is caused by a germ-line mutation in MEN-1 gene encoding a tumour suppressor protein, menin. This review presents clinical expressions, diagnosis and management of the MEN-1 syndrome. Properties and mechanisms of menin functions are also reviewed.

Publication types

Review

MeSH terms

Gastrinoma / diagnosis
Gastrinoma / genetics
Gene Expression
Humans
Hyperparathyroidism / diagnosis
Hyperparathyroidism / genetics
Insulinoma / diagnosis
Insulinoma / genetics
Multiple Endocrine Neoplasia Type 1 / diagnosis
Multiple Endocrine Neoplasia Type 1 / genetics*
Multiple Endocrine Neoplasia Type 1 / therapy
Mutation
Prolactinoma / diagnosis
Prolactinoma / genetics
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / physiology*

Substances

MEN1 protein, human
Proto-Oncogene Proteins