The Claisen rearrangement approach to fused bicyclic medium-ring oxacycles

Org Biomol Chem. 2008 Feb 21;6(4):693-702. doi: 10.1039/b715354f. Epub 2008 Jan 4.

Abstract

The synthesis of five fused-bicyclic medium-ring lactones carrying identical ring-fusion to that in the polyether toxins is described using an enolate hydroxylation, intramolecular hydrosilation, Claisen rearrangement sequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Crystallography, X-Ray
  • Hydroxylation
  • Lactones / chemical synthesis*
  • Lactones / chemistry

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Lactones