Abstract
Three new 3,4- seco-lanostanes, kadsuracoccinic acids A-C ( 1- 3), were isolated from the medicinal plant Kadsura coccinea, in addition to the known compounds kadsuric acid ( 4) and micranoic acid A ( 5). The structures of 1- 3 were elucidated by analysis of their 2D-NMR spectroscopic data. Furthermore, the relative conformation of 1 was confirmed by an X-ray crystallographic study. This is the first report of a 3,4- seco-lanostane-type triterpene with a 17(20)-ene functional group. Treatment of cultured individual Xenopus laevis cells with 1 at the blastular stage arrested cleavage of these cells with an IC 50 of 0.32 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Division / drug effects*
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Crystallography, X-Ray
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Kadsura / chemistry*
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Lanosterol / analogs & derivatives*
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Lanosterol / chemistry
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Lanosterol / isolation & purification*
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Lanosterol / pharmacology*
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Molecular Conformation
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Molecular Structure
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Plants, Medicinal / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
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Xenopus laevis / embryology*
Substances
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Drugs, Chinese Herbal
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Triterpenes
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kadsuracoccinic acid A
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kadsuracoccinic acid B
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kadsuracoccinic acid C
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Lanosterol