Abstract
The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antitubercular / pharmacology*
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Codon / genetics
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Drug Resistance, Bacterial
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Genotype
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HIV Infections / complications*
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HIV Infections / epidemiology
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HIV Infections / virology
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HIV-1
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Humans
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Microbial Sensitivity Tests
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Mutation
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Polymorphism, Single Nucleotide
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Prevalence
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Rifampin / pharmacology*
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South Africa / epidemiology
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Tuberculosis, Multidrug-Resistant / complications*
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / microbiology
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Tuberculosis, Multidrug-Resistant / transmission*
Substances
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Antibiotics, Antitubercular
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Codon
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Rifampin