An efficient and straightforward access to sulfur substituted [2.2]paracyclophanes: application to stereoselective sulfenate salt alkylation

Org Lett. 2008 Mar 20;10(6):1271-4. doi: 10.1021/ol800161m. Epub 2008 Feb 15.

Abstract

A straightforward and high-yielding access to various [2.2]paracyclophanes possessing a sulfur-based functional group is reported, the key step being a SEAr reaction mediated by a sulfonium salt. The versatility of the methodology was exemplified by an original application in sulfenate salt chemistry, from which a remarkable chirality transfer was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Macrocyclic Compounds / chemistry*
  • Models, Molecular
  • Stereoisomerism
  • Sulfur / chemistry*

Substances

  • Macrocyclic Compounds
  • Sulfur