Patent ductus venosus (PDV) is a very rare congenital vascular anomaly of the liver. We report a 17-year-old male patient presenting with elevated liver enzymes and multiple liver masses. Physical examination was normal except for pectus excavatum deformity. Ultrasonography revealed multiple tumor-like lesions of the liver and a dilated portal vein with mild splenomegaly. Liver biopsy obtained from liver parenchyma revealed minimal hepatocellular damage. PDV was diagnosed by CT (computed tomography) portography. The radiologic findings of chronic liver disease and multiple liver masses were attributed to presence of PDV. Although it is very rare, PDV might be a diagnostic possibility in patients with mass lesions in the liver.