Regioselective C-H functionalization directed by a removable carboxyl group: palladium-catalyzed vinylation at the unusual position of indole and related heteroaromatic rings

Org Lett. 2008 Mar 20;10(6):1159-62. doi: 10.1021/ol8000602. Epub 2008 Feb 16.

Abstract

The palladium-catalyzed oxidative vinylation of indole-3-carboxylic acids with alkenes effectively proceeds via directed C-H functionalization and decarboxylation to produce the corresponding 2-vinylated indoles. Similarly, pyrrole-, furan-, and thiophenecarboxylic acids also undergo decarboxylative vinylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Heterocyclic Compounds / chemistry*
  • Indoles / chemistry*
  • Palladium / chemistry*

Substances

  • Heterocyclic Compounds
  • Indoles
  • Palladium