Abstract
The processing of spatial information is the focus of interest for many cognitive neuroscientists. Approximately 10 years ago, a novel behavioral paradigm called active allothetic place avoidance (AAPA) was designed allowing the simultaneous assessment of locomotor and spatial behavior. The present study describes the effect of the combined treatment of Long-Evans rats with alpha1-adrenergic and D2 antagonists prazosin (1mg/kg and 2 mg/kg) and sulpiride (10 mg/kg and 30 mg/kg) on locomotion and avoidance behavior in the AAPA task. Results show that co-application of both drugs leads to disturbances in locomotion and avoidance in rats at the doses, which caused no impairments when administered independently. This finding suggests that both types of receptors act synergistically to regulate locomotion and possibly spatial behavior.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Antagonists / administration & dosage
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Analysis of Variance
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Animals
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Association Learning / drug effects
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Association Learning / physiology
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Avoidance Learning / drug effects
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Avoidance Learning / physiology*
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Dopamine Antagonists / administration & dosage
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Dose-Response Relationship, Drug
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Drug Synergism
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Environment
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Male
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Motor Activity / drug effects
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Motor Activity / physiology*
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Prazosin / administration & dosage
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Rats
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Rats, Long-Evans
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Receptor Cross-Talk / physiology*
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Receptors, Adrenergic, alpha-1 / drug effects
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Receptors, Adrenergic, alpha-1 / metabolism*
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Receptors, Dopamine D2 / drug effects
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Receptors, Dopamine D2 / metabolism*
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Spatial Behavior / drug effects
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Spatial Behavior / physiology*
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Sulpiride / administration & dosage
Substances
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Adrenergic alpha-Antagonists
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Dopamine Antagonists
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Receptors, Adrenergic, alpha-1
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Receptors, Dopamine D2
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Sulpiride
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Prazosin