Abstract
5-FU is among the drugs most frequently used in the treatment of gastrointestinal malignancies. Also, it has been reported to reveal severe side effects in the case of a dihydropyrimidine dehydrogenase (DPD) deficiency. A 75-year-old man showed severe nausea and vomiting after administration of UFT/Uzel as adjuvant chemotherapy. Because of severe thrombocytopenia and grade 4 neutropenia, platelet transfusion and G-CSF administration were performed. With time, the leukocyte, neutrophil and platelet count recovered to normal level. We strongly suspected a DPD deficiency from the result of urinary pyrimidine analysis.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Chemotherapy, Adjuvant
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Dihydropyrimidine Dehydrogenase Deficiency*
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Dihydrouracil Dehydrogenase (NAD+) / deficiency*
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Dihydrouracil Dehydrogenase (NAD+) / metabolism*
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Dihydrouracil Dehydrogenase (NADP) / metabolism*
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Humans
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Male
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Rectal Neoplasms / drug therapy
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Rectal Neoplasms / surgery
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Tegafur / administration & dosage
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Tegafur / adverse effects
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Tegafur / therapeutic use
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Uracil / administration & dosage
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Uracil / adverse effects
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Uracil / therapeutic use
Substances
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Tegafur
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Uracil
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Dihydrouracil Dehydrogenase (NAD+)
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Dihydrouracil Dehydrogenase (NADP)