Abstract
The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Hemin / genetics*
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Humans
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Microbial Sensitivity Tests
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Mutation*
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Phenotype
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Staphylococcus aureus / classification
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / growth & development
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Vancomycin / pharmacology*
Substances
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Anti-Bacterial Agents
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Vancomycin
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Hemin