Abstract
In the present work, we evaluated the effect of gatifloxacin on the evolution of experimental murine infection with Nocardia brasiliensis using linezolid as a control. Gatifloxacin was injected subcutaneously at 100 mg/kg body weight every 8 h for 4 weeks. This compound was equally as efficient as linezolid in reducing the production of lesions.
MeSH terms
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Acetamides / administration & dosage
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Acetamides / therapeutic use
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Disease Models, Animal*
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Female
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Fluoroquinolones / administration & dosage
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Fluoroquinolones / therapeutic use*
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Gatifloxacin
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Humans
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Linezolid
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Mice
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Mice, Inbred BALB C
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Nocardia / classification
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Nocardia / drug effects*
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Nocardia Infections / drug therapy*
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Nocardia Infections / microbiology
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Oxazolidinones / administration & dosage
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Oxazolidinones / therapeutic use
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Treatment Outcome
Substances
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Acetamides
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Anti-Bacterial Agents
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Fluoroquinolones
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Oxazolidinones
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Linezolid
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Gatifloxacin