Abstract
Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
MeSH terms
-
Amidohydrolases / antagonists & inhibitors*
-
Amidohydrolases / metabolism
-
Animals
-
Binding Sites
-
Humans
-
Oxazoles / chemical synthesis
-
Oxazoles / chemistry
-
Oxazoles / pharmacology*
-
Pain / drug therapy*
-
Pain / enzymology*
-
Pain Measurement / drug effects*
-
Pyridines / pharmacology
-
Rats
-
Spinal Nerves / drug effects*
-
Spinal Nerves / injuries
-
Structure-Activity Relationship
Substances
-
1-oxo-1-(5-(2-pyridyl)-2-yl)-7-phenylheptane
-
Oxazoles
-
Pyridines
-
Amidohydrolases
-
fatty-acid amide hydrolase