Four new steroids, stoloniferones R-T (1-3), and (25S)-24-methylenecholestane-3 beta,5 alpha,6 beta-triol-26-acetate (4) were isolated from the methylene chloride solubles of the soft coral Clavularia viridis. The structures of the metabolites were elucidated by extensive spectral analysis and their anti-inflammatory activity was measured in vitro.