Abstract
In the American black population, DRw8 is commonly found in association with DQw7 and an undefined HLA-D specificity. Polymerase chain reaction amplification was used to obtain DRB1 cDNA clones from two unrelated individuals expressing this haplotype. The DRB1 sequence is most similar to a sequence found in cells expressing DRw8, DQw4, Dw8.2 differing at the protein level by a single amino acid substitution at position 86.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Base Sequence
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Black People / genetics*
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Black or African American
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DNA / analysis
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Genetic Variation / genetics*
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HLA-DQ Antigens / genetics*
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HLA-DR Antigens / genetics*
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HLA-DR Serological Subtypes
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HLA-DRB1 Chains
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Haplotypes
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Histocompatibility Antigens Class II / genetics*
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Humans
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Lymphocyte Culture Test, Mixed
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Molecular Sequence Data
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Oligonucleotide Probes
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Polymerase Chain Reaction
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United States
Substances
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HLA-DQ Antigens
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HLA-DQ7 antigen
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HLA-DR Antigens
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HLA-DR Serological Subtypes
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HLA-DR8 antigen
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HLA-DRB1 Chains
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Histocompatibility Antigens Class II
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Oligonucleotide Probes
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DNA