Acne causes substantial social, emotional, and psychological effects in both adolescents and adults. Although current therapies can effectively treat the disease and its related effects, adherence to these treatment regimens often is poor. Misconceptions about the cause of acne, unrealistic treatment expectations, the chronic and partially asymptomatic nature of the disease, difficulty incorporating treatment into daily activities, and the need for long-term therapy contribute to overall adherence. To improve adherence, physicians must counter these factors with skilled counseling; consideration of the patient's perspective; effective means of educating the patient; and simple, effective, tolerable regimens that are compatible with the patient's lifestyle.