Type I interferon response to cytomegalovirus infection: the kick-start

Nassima Fodil-Cornu; Silvia M Vidal

doi:10.1016/j.chom.2008.01.005

Type I interferon response to cytomegalovirus infection: the kick-start

Cell Host Microbe. 2008 Feb 14;3(2):59-61. doi: 10.1016/j.chom.2008.01.005.

Authors

Nassima Fodil-Cornu¹, Silvia M Vidal

Affiliation

¹ Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada.

PMID: 18312838
DOI: 10.1016/j.chom.2008.01.005

Abstract

Host responses to cytomegalovirus infection include initial early production of alpha and beta interferons, also called type I interferons, which are elicited directly by viral products via Toll-like receptors. New data indicate that, preceding these events, an earlier critical type I interferon elicited in primary infected stromal cells via the lymphotoxin beta receptor system and mediated by B cells is necessary to kick-start an efficient antiviral response.

Publication types

Comment
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
B-Lymphocytes / metabolism
Cytomegalovirus Infections / immunology*
Interferon Type I / immunology*
Lymphotoxin alpha1, beta2 Heterotrimer / metabolism
Lymphotoxin beta Receptor / metabolism
Mice
Muromegalovirus / immunology*
Stromal Cells / immunology
Stromal Cells / metabolism
Toll-Like Receptors / metabolism

Substances

Interferon Type I
Lymphotoxin alpha1, beta2 Heterotrimer
Lymphotoxin beta Receptor
Toll-Like Receptors