Abstract
Ghrelin, a powerful appetite-stimulating hormone secreted by the stomach, is modified by an octanyl side chain on its third amino acid, a serine, which is essential for its activity. A recent study (Yang et al., 2008) reports identification of the enzyme catalyzing the addition of this octanyl, GOAT.
MeSH terms
-
Acyltransferases / antagonists & inhibitors
-
Acyltransferases / metabolism*
-
Animals
-
Appetite Regulation* / drug effects
-
Cell Line
-
Cloning, Molecular
-
Enzyme Inhibitors / pharmacology
-
Ghrelin / metabolism*
-
Humans
-
Membrane Proteins
-
Mice
-
Receptors, Ghrelin / metabolism
-
Recombinant Proteins / metabolism
-
Serine / metabolism
Substances
-
Enzyme Inhibitors
-
Ghrelin
-
Membrane Proteins
-
Receptors, Ghrelin
-
Recombinant Proteins
-
ghrelin, des-n-octanoyl
-
Serine
-
Acyltransferases
-
Mboat4 protein, mouse