1,2-Alkyl migration as a key element in the invention of cascade reactions catalyzed by pi-acids

Chemistry. 2008;14(12):3514-22. doi: 10.1002/chem.200701985.

Abstract

This brief overview highlights recent progress in the field of cascade reactions that are initiated by the activation of a pi-system using platinum and gold catalysts and that are coupled with a 1,2-alkyl migration step. While the reactions discussed aim to rapidly evolve molecular complexity, they are experimentally straightforward and easy to perform. Primarily guided by the type of 1,2-alkyl migration, methods are categorized as shifts to metal carbenoid centers and pinacol-type rearrangements.