Abstract
The expression of I-A antigen in rat peritoneal cells was significantly reduced during infection with Cryptococcus neoformans. When studying the in vitro action of T-suppressor cells induced by the fungus, or a soluble factor from the T-suppressor cells, a significant decrease in I-A expression by the peritoneal cells was observed. This expression was partially restored by indomethacin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cryptococcosis / immunology*
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Cryptococcus neoformans / immunology*
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Histocompatibility Antigens Class II / antagonists & inhibitors*
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Histocompatibility Antigens Class II / biosynthesis
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Indomethacin / pharmacology
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Macrophages / immunology*
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Peritoneal Cavity / cytology
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Rats
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T-Lymphocytes, Regulatory / immunology*
Substances
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Histocompatibility Antigens Class II
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Indomethacin