We present a case report of a man with atherosclerotic involvement of a left main trifurcation treated by the Venture wire control catheter. The patient was submitted to primary percutaneous transluminal coronary angioplasty (PTCA) in a primary center for acute occlusion of the left anterior descending artery, then he was transferred to our tertiary center to perform left main trifurcation revascularization that was unsuccessful by traditional approach. In our high volume center (operator >600 PTCA/year) as well, the attempts at crossing the lesion with a number of different guidewires failed because of the extreme angulation of the circumflex artery. At last, a successful attempt was reached using the Venture wire control, a low profile catheter with a tip that can be deflected up to 90 degrees . Once the lesion was crossed and wiring of other branches obtained, crush stenting of the left anterior descending artery and intermediate ramus and T-stent of the circumflex artery were performed with an optimal angiographic result.