Abstract
The microcapsules with entrapped herbal water-soluble extracts Plantago major and Calendula officinalis L. (HE) were prepared by LbL-adsorption of carrageenan and modificated chitosan onto CaCO3 microparticles with their subsequent dissolving after the treatment of EDTA. Entrapment of HE was performed by adsorption and co-precipitation techniques. The co-precipitation provided better entrapment of HE compared to adsorption. In vitro release kinetics in an artificial gastric juice (AGJ) was studied. The HE release was shown to accelerate gastric ulcer treatment in a rat model.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption
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Animals
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Calcium Carbonate / chemistry
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Calendula* / chemistry
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Capsules / chemistry
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Capsules / pharmacokinetics
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Capsules / pharmacology*
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Carrageenan / chemistry
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Carrageenan / pharmacokinetics
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Carrageenan / pharmacology
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Chitosan / chemistry
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Chitosan / pharmacokinetics
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Chitosan / pharmacology
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Disease Models, Animal
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Edetic Acid / chemistry
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Gastric Juice / chemistry
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Male
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Plant Extracts / chemistry
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Plant Extracts / pharmacokinetics
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Plant Extracts / pharmacology*
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Plantago* / chemistry
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Rats
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Stomach Ulcer / drug therapy*
Substances
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Capsules
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Plant Extracts
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Carrageenan
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Chitosan
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Edetic Acid
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Calcium Carbonate