Synthesis and preliminary evaluation of aminoalkanol derivatives of selected azatricycloundecane system for binding with beta-adrenergic and 5HT1A and 5HT2A receptors

Jerzy Kossakowski; Bozena Kuran

Synthesis and preliminary evaluation of aminoalkanol derivatives of selected azatricycloundecane system for binding with beta-adrenergic and 5HT1A and 5HT2A receptors

Acta Pol Pharm. 2007 Nov-Dec;64(6):527-33.

Authors

Jerzy Kossakowski¹, Bozena Kuran

Affiliation

¹ Department of Medical Chemistry, Medical University, 3 Oczki Str., 02-007 Warszawa, Poland. [email protected]

PMID: 18323247

Abstract

A series of aminoalkanol derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)] undec-8-en-1-yl acetate and 1,11-dimethyl-4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione was prepared. The pharmacological profile of selected compounds was evaluated for affinity to beta-adrenoreceptors and serotoninergic receptors (5HT1A and 5HT2A).

MeSH terms

Amino Alcohols / chemical synthesis
Amino Alcohols / pharmacology*
Animals
Binding Sites
Cerebral Cortex / metabolism
In Vitro Techniques
Radioligand Assay
Rats
Receptor, Serotonin, 5-HT1A / metabolism*
Receptor, Serotonin, 5-HT2A / metabolism*
Receptors, Adrenergic, beta / metabolism*
Structure-Activity Relationship

Substances

Amino Alcohols
Receptor, Serotonin, 5-HT2A
Receptors, Adrenergic, beta
Receptor, Serotonin, 5-HT1A