Detection of autoantibodies against NMDA-type glutamate receptor in a patient with recurrent optic neuritis and transient cerebral lesions

Neuropediatrics. 2007 Oct;38(5):257-60. doi: 10.1055/s-2007-1004521.

Abstract

We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum and cerebrospinal fluid. Results of this case study suggest that the development of autoantibodies against NMDA-type glutamate receptors may play a role in the pathogenesis of central nervous system demyelinating diseases.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood*
  • Child
  • Diagnosis, Differential
  • Dominance, Cerebral / physiology
  • Encephalomyelitis, Acute Disseminated / diagnosis
  • Encephalomyelitis, Acute Disseminated / immunology*
  • Epilepsy, Partial, Motor / diagnosis
  • Epilepsy, Partial, Motor / immunology
  • Epilepsy, Tonic-Clonic / diagnosis
  • Epilepsy, Tonic-Clonic / immunology
  • Female
  • Follow-Up Studies
  • Frontal Lobe / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / immunology*
  • Neuromyelitis Optica / diagnosis
  • Neuromyelitis Optica / immunology*
  • Optic Nerve / pathology
  • Optic Neuritis / immunology*
  • Parietal Lobe / pathology
  • Receptors, Glutamate / immunology
  • Receptors, N-Methyl-D-Aspartate / immunology*
  • Recurrence

Substances

  • Autoantibodies
  • NR2B NMDA receptor
  • Receptors, Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • glutamate receptor delta 2