Abstract
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside and nonnucleoside polymerase inhibitors.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Line, Tumor
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Drug Resistance, Viral
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Drug Synergism
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Hepacivirus / drug effects*
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Humans
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Molecular Structure
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Phenylthiourea / analogs & derivatives
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Phenylthiourea / chemistry
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Phenylthiourea / pharmacology
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Protease Inhibitors / chemistry
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Protease Inhibitors / pharmacology*
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RNA-Dependent RNA Polymerase / antagonists & inhibitors*
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Viral Nonstructural Proteins / antagonists & inhibitors*
Substances
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1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea
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Antiviral Agents
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NS4A protein, flavivirus
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Protease Inhibitors
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Viral Nonstructural Proteins
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Phenylthiourea
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RNA-Dependent RNA Polymerase