A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

Science. 1991 Oct 11;254(5029):274-7. doi: 10.1126/science.254.5029.274.

Abstract

The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Mice
  • Mink
  • Mink Cell Focus-Inducing Viruses / genetics
  • Molecular Sequence Data
  • Oncogene Protein v-akt
  • Oncogenes / genetics*
  • Protein Kinases / genetics*
  • Protein Serine-Threonine Kinases
  • Protein-Tyrosine Kinases / genetics*
  • Retroviridae Proteins, Oncogenic / genetics*
  • Sequence Homology, Nucleic Acid

Substances

  • Retroviridae Proteins, Oncogenic
  • Protein Kinases
  • Protein-Tyrosine Kinases
  • Oncogene Protein v-akt
  • Protein Serine-Threonine Kinases

Associated data

  • GENBANK/M61767