Thromboembolic disease after combined anterior/posterior reconstruction for adult spinal deformity: a prospective cohort study using magnetic resonance venography

Spine (Phila Pa 1976). 2008 Mar 15;33(6):668-72. doi: 10.1097/BRS.0b013e318166dfa3.

Abstract

Study design: Thromboembolic disease (TED) after anterior/posterior spinal reconstructions was prospectively evaluated in 66 consecutive patients.

Objective: Determine the incidence of TED after anterior/posterior spinal reconstruction.

Summary of background data: Few studies have examined the rate of TED after potentially high-risk combined anterior/posterior reconstructions. Magnetic resonance venography (MRV) is more effective at detecting pelvic deep venous thrombosis (DVT) than conventional screening, but has not been used in these patients.

Methods: We undertook a prospective cohort study of 66 consecutive adult patients (mean, 52.7 +/- 9.6 years) undergoing combined anterior/posterior spinal reconstructions for spinal deformity. All patients received only mechanical DVT prophylaxis. After surgery, MRV and bilateral lower extremity Doppler ultrasounds were obtained to screen for DVT, and contrast-enhanced spiral computed tomography scans were obtained for clinical suspicion of pulmonary embolism (PE).

Results: The total incidence of postoperative TED was 13.6% (9 patients). The overall rate of DVT was 9.1% (6 patients), one-third occurring in the pelvis. PE developed in 7.6% (5 patients). In 2 patients, PE developed less than 48 hours after positive dopplers. In 3 patients, PE developed despite negative screening studies. Right-sided thoracoabdominal approaches were associated with an increased risk of developing DVT (P = 0.03, Odds Ratio 9.8), PE (P = 0.01, Odds Ratio 20), and TED (P = 0.004, Odds Ratio 12).

Conclusion: We report a high rate of TED after extensive anterior/posterior spinal reconstructions, for which a right-sided thoracoabdominal approach is an independent risk factor and screening ineffective at preventing PE. These patients should be considered at high risk for postoperative TED.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Phlebography / methods
  • Plastic Surgery Procedures / methods*
  • Postoperative Complications / pathology
  • Postoperative Complications / surgery
  • Prospective Studies
  • Spinal Cord / abnormalities*
  • Spinal Cord / pathology
  • Spinal Cord / surgery*
  • Thromboembolism / etiology
  • Thromboembolism / pathology
  • Thromboembolism / surgery*