Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions

Susanne Perkhofer; Daniel Jost; Manfred P Dierich; Cornelia Lass-Flörl

doi:10.1128/AAC.01572-07

Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions

Antimicrob Agents Chemother. 2008 May;52(5):1873-5. doi: 10.1128/AAC.01572-07. Epub 2008 Mar 17.

Authors

Susanne Perkhofer¹, Daniel Jost, Manfred P Dierich, Cornelia Lass-Flörl

Affiliation

¹ Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. [email protected]

Abstract

MICs and fractional inhibitory concentrations were evaluated for anidulafungin and voriconazole alone and in combination against conidia and hyphae under hypoxic (1% oxygen-5% CO(2)-94% nitrogen) conditions against 31 Aspergillus isolates. Anidulafungin exhibited excellent activity against conidia and hyphae of Aspergillus spp. The visual reading of the MIC for anidulafungin was optimal under hypoxic conditions.

MeSH terms

Anaerobiosis
Anidulafungin
Antifungal Agents / pharmacology
Aspergillus / drug effects*
Aspergillus fumigatus / drug effects
Drug Synergism
Echinocandins / pharmacology*
Hyphae / drug effects*
Microbial Sensitivity Tests
Pyrimidines / pharmacology*
Spores, Fungal / drug effects*
Triazoles / pharmacology*
Voriconazole

Substances

Antifungal Agents
Echinocandins
Pyrimidines
Triazoles
Anidulafungin
Voriconazole