Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

M Szybka; I Zawlik; D Kulczycka; E Golanska; E Jesien; D Kupnicka; R Stawski; S Piaskowski; E Bieniek; M Zakrzewska; R Kordek; P P Liberski; P Rieske

doi:10.1038/sj.bjc.6604258

Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

Br J Cancer. 2008 Apr 22;98(8):1431-3. doi: 10.1038/sj.bjc.6604258. Epub 2008 Mar 18.

Authors

M Szybka¹, I Zawlik, D Kulczycka, E Golanska, E Jesien, D Kupnicka, R Stawski, S Piaskowski, E Bieniek, M Zakrzewska, R Kordek, P P Liberski, P Rieske

Affiliation

¹ Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93-509, Poland.

Abstract

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Brain Neoplasms / genetics*
Female
Genes, p53*
Glioblastoma / genetics*
Humans
Loss of Heterozygosity
Male
Middle Aged
Mutation*
Promoter Regions, Genetic
RNA, Messenger / analysis*
Tumor Suppressor Protein p53 / genetics*

Substances

RNA, Messenger
Tumor Suppressor Protein p53