Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases

Intensive Care Med. 2008 Aug;34(8):1384-92. doi: 10.1007/s00134-008-1056-1. Epub 2008 Mar 19.

Abstract

Objective: Recent experimental evidence suggests that matrix metalloproteinases (MMPs) are implicated in the pathophysiology of traumatic brain injury (TBI) by increasing blood-brain barrier permeability and exacerbating posttraumatic edema. We examined the acute profile of MMP-2 and MMP-9 in the plasma of patients with moderate or severe TBI and in the brain extracellular fluid (ECF).

Design: Prospective observational study.

Setting: Neurotraumatology intensive care unit of a tertiary university hospital.

Patients: Twenty patients with moderate or severe TBI were included and three groups were used as controls: 20 patients with a mild head injury and normal CT scan, 15 moderate polytrauma patients without TBI, and 20 healthy volunteers.

Interventions: Plasma samples were collected within the first 12[Symbol: see text]h and at 24[Symbol: see text]h post-injury. Simultaneous brain microdialysate and plasma samples were obtained in four moderate-severe TBI patients at additional timepoints: 48, 72, and 96[Symbol: see text]h post-TBI.

Measurements and main results: Gelatinases (MMP-2 and MMP-9) were measured by gelatin zymography. A significant increase in plasma gelatinases was observed at baseline when compared with healthy volunteers in the study group. This early increase was followed by a significant decrease at 24[Symbol: see text]h post-injury. Brain microdialysis samples presented a similar time profile as plasma samples for both gelatinases.

Conclusions: High levels of gelatinases were found in plasma and brain ECF in the early phase of TBI, indicating that both local and systemic trauma-induced upregulation of gelatinases in the acute phase might play an important role in the pathophysiology of TBI and could be a future therapeutic target.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood-Brain Barrier*
  • Brain Injuries / classification
  • Brain Injuries / metabolism*
  • Brain Injuries / physiopathology
  • Extracellular Fluid / metabolism*
  • Female
  • Gelatinases / metabolism*
  • Glasgow Coma Scale
  • Humans
  • Injury Severity Score
  • Male
  • Matrix Metalloproteinase 2 / blood*
  • Matrix Metalloproteinase 9 / blood*
  • Microdialysis / methods
  • Prospective Studies

Substances

  • Gelatinases
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9