A new mechanism of release from senescence: suppression of p16INK4a by beta-catenin

Pigment Cell Melanoma Res. 2008 Feb;21(1):5-6. doi: 10.1111/j.1755-148X.2007.00434.x.
No abstract available

Publication types

  • News

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism*
  • Down-Regulation
  • Gene Expression Regulation, Neoplastic
  • Genes, ras
  • Humans
  • Melanocytes / metabolism*
  • Melanocytes / pathology
  • Melanoma, Experimental / genetics
  • Melanoma, Experimental / metabolism*
  • Melanoma, Experimental / pathology
  • Mice
  • Mice, Transgenic
  • Mutation
  • beta Catenin / genetics
  • beta Catenin / metabolism*

Substances

  • CTNNB1 protein, human
  • CTNNB1 protein, mouse
  • Cdkn2a protein, mouse
  • Cyclin-Dependent Kinase Inhibitor p16
  • beta Catenin