Abstract
During reverse transcription, an RNA polypurine tract (PPT) resists digestion by reverse transcriptase (RT) and primes plus-strand DNA synthesis. In this issue of Chemistry & Biology, Yi-Brunozzi et al. (2008) report structural studies of PPTs, illuminating how they are recognized by RT.
MeSH terms
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Base Composition
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Base Sequence
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Binding Sites
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DNA, Viral / chemistry*
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DNA, Viral / genetics
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DNA, Viral / metabolism
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HIV Reverse Transcriptase / metabolism
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Purine Nucleotides / chemistry*
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Purine Nucleotides / genetics
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Purine Nucleotides / metabolism
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RNA, Viral / chemistry*
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RNA, Viral / genetics
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RNA, Viral / metabolism
Substances
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DNA, Viral
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Purine Nucleotides
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RNA, Viral
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HIV Reverse Transcriptase