Abstract
In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3-OH (4a-f) or 2-OH group (7a-c) of ascorbic acid (ASA). Log Ps and pK(a)s of these products were experimentally evaluated. All the compounds were tested for their antioxidant activity on lipidic peroxidation induced by Fe(3+)-ADP/NADPH in lipids of microsomal membranes of rat hepatocytes. Only 3-O series displays antioxidant activity and it seems to be principally dependent on the lipophilicity. Both series trigger in vitro NO-dependent vasodilator properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry*
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Antioxidants / classification
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Aorta, Thoracic / drug effects
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Ascorbic Acid / chemical synthesis*
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Ascorbic Acid / chemistry
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Ascorbic Acid / classification
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Dose-Response Relationship, Drug
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Lipid Peroxidation / drug effects
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Lipids / chemistry
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Magnetic Resonance Spectroscopy
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Male
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Microsomes / drug effects
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Molecular Structure
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Nitric Oxide Donors / chemical synthesis*
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Nitric Oxide Donors / chemistry
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Nitric Oxide Donors / classification
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Rats
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Rats, Wistar
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Stereoisomerism
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Structure-Activity Relationship
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Time Factors
Substances
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Antioxidants
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Lipids
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Nitric Oxide Donors
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Ascorbic Acid