Taking apart the endocytic machinery

J Cell Biol. 2008 Mar 24;180(6):1059-60. doi: 10.1083/jcb.200802174.

Abstract

The formation of clathrin-coated endocytic vesicles is driven by a complex and highly dynamic molecular machinery. In this issue, Idrissi et al. (Idrissi, F.-Z., H. Grötsch, I.M. Fernández-Golbano, C. Presciatto-Baschong, H. Riezman, and M.-I. Geli. 2008. J. Cell Biol. 180:1219-1232) reveal some of the secrets of this machinery by analyzing the localizations of nine endocytic proteins during vesicle budding in yeast using quantitative immunoelectron microscopy.

Publication types

  • Review
  • Comment

MeSH terms

  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure
  • Clathrin / metabolism
  • Clathrin-Coated Vesicles / metabolism*
  • Clathrin-Coated Vesicles / ultrastructure
  • Endocytosis / physiology*
  • Gene Expression Regulation, Fungal / genetics
  • Microscopy, Immunoelectron / methods
  • Protein Transport
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae / ultrastructure
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Transport Vesicles / metabolism*
  • Transport Vesicles / ultrastructure

Substances

  • Clathrin
  • Saccharomyces cerevisiae Proteins