Anaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization

Pediatr Hematol Oncol. 2008 Mar;25(2):131-4. doi: 10.1080/08880010701885268.

Abstract

Methotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy for ALL. A desensitization protocol was followed and MTX tolerance has been successfully achieved, allowing this patient to complete the needed chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Anaphylaxis / therapy*
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antimetabolites, Antineoplastic / adverse effects*
  • Child
  • Desensitization, Immunologic*
  • Drug Hypersensitivity / therapy*
  • Humans
  • Injections, Spinal
  • Leukemia-Lymphoma, Adult T-Cell / complications
  • Leukemia-Lymphoma, Adult T-Cell / drug therapy*
  • Male
  • Methotrexate / administration & dosage*
  • Methotrexate / adverse effects*

Substances

  • Antimetabolites, Antineoplastic
  • Methotrexate