Objective: To explore the clinical significance of CP2, CA125, salicylic acid (SA) and carcinoembryonic antigen (CEA) in endometrial carcinoma patients.
Methods: A retrospective study was carried out on 154 cases of endometrial carcinoma with tumor markers test results who were admitted to our department from Aug 1992 to Nov 2004.
Results: The patients were followed up for (38+/-28) months. 23.4%, 36.8%, 19.0% and 30.3% of cases were with abnormal values of CP2, SA, CA125 and CEA. CP2 abnormal level was related with the stage, cell differentiation, adnexa metastasis, positive peritoneal cytology and pelvic lymph node metastasis (P=0.002, P=0.040, P=0.019, P=0.019, P=0.005). SA abnormal level was related with the adnexa metastasis and positive peritoneal cytology (P=0.021, P=0.000). CA125 abnormal level was related with the cell differentiation, cervical metastasis and pelvic lymph node metastasis (P=0.014, P=0.006, P=0.018). The survival was related with CP2, CA125 and CEA (P=0.016, P=0.000, P=0.016), especially CA125.
Conclusions: Among the commonly used tumor markers, CP2 is related with many clinical pathological parameters. CA125 elevation may strongly suggest worse prognosis.