[Complex morphological approach to assessment of protective properties of preparations for cholera specific prophylaxis]

S A Bugorkova; S Iu Zadumina; T V Bugorkova; E Iu Lotsmanova; A L Kravtsov; T N Shchukovskaia; V V Kutyrev

[Complex morphological approach to assessment of protective properties of preparations for cholera specific prophylaxis]

Zh Mikrobiol Epidemiol Immunobiol. 2008 Jan-Feb:(1):31-4.

[Article in Russian]

Authors

S A Bugorkova, S Iu Zadumina, T V Bugorkova, E Iu Lotsmanova, A L Kravtsov, T N Shchukovskaia, V V Kutyrev

PMID: 18368749

Abstract

Using developed scheme, complex study of protective properties of avirulent recombinant strain Vibrio cholerae El Tor Inaba KM 184 was performed. Necessity for broadening of standard procedure of testing of cholera vaccines protective properties by using of quantitative methods of assessment of morphological changes and state of biomodel's functional systems, which could increase the information value of assessment of studied vaccines, was experimentally substantiated.

Publication types

English Abstract

MeSH terms

Administration, Oral
Animals
Cholera / physiopathology*
Cholera / prevention & control*
Cholera Toxin / biosynthesis
Cholera Toxin / genetics
Cholera Vaccines / administration & dosage*
Evaluation Studies as Topic*
Peptide Fragments / biosynthesis
Peptide Fragments / genetics
Rabbits
Vaccination*
Vaccines, Attenuated / administration & dosage
Vaccines, Synthetic / administration & dosage
Vibrio cholerae O1 / immunology*
Vibrio cholerae O1 / metabolism
Viscera / physiopathology

Substances

Cholera Vaccines
Peptide Fragments
Vaccines, Attenuated
Vaccines, Synthetic
cholera toxin, B subunit (50-64)
Cholera Toxin