Complete resolution of Paget disease of the vulva with imiquimod cream

J Low Genit Tract Dis. 2008 Apr;12(2):90-4. doi: 10.1097/LGT.0b013e31815a58a5.

Abstract

Extra mammary Paget disease (EMPD) is a neoplastic disease of apocrine gland bearing skin. Surgical excision is the standard of care for EMPD; however, it is accompanied by recurrence in more than 60% of the patients. Recently, imiquimod cream has been reported to induce complete responses in primary or recurrent EMPD. We report on 2 women with vulva EMPD who achieved biopsy-confirmed resolution of their disease after topical application of imiquimod 5% cream.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Aged
  • Aminoquinolines / administration & dosage*
  • Antineoplastic Agents / administration & dosage*
  • Biopsy
  • Female
  • Follow-Up Studies
  • Humans
  • Imiquimod
  • Male
  • Ointments
  • Paget Disease, Extramammary / drug therapy*
  • Paget Disease, Extramammary / pathology
  • Vaginal Creams, Foams, and Jellies
  • Vulvar Neoplasms / drug therapy*
  • Vulvar Neoplasms / pathology

Substances

  • Aminoquinolines
  • Antineoplastic Agents
  • Ointments
  • Vaginal Creams, Foams, and Jellies
  • Imiquimod