Abstract
The ability of daptomycin to produce bactericidal activity against Staphylococcus aureus while causing negligible cell lysis has been demonstrated using electron microscopy and the membrane integrity probes calcein and ToPro3. The formation of aberrant septa on the cell wall, suggestive of impairment of the cell division machinery, was also observed.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacteriolysis / physiology*
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Cell Membrane / drug effects
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Cell Membrane / ultrastructure
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Daptomycin / pharmacology*
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Fluoresceins
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Fluorescent Dyes
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Microscopy, Electron, Transmission
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / ultrastructure
Substances
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Anti-Bacterial Agents
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Fluoresceins
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Fluorescent Dyes
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Daptomycin
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fluorexon