Abstract
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / pharmacology*
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Behavior, Animal / drug effects
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Chemical Phenomena
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Chemistry, Physical
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Convulsants
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Dose-Response Relationship, Drug
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Drug Design
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Electroshock
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mice
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Models, Molecular
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / pharmacology*
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Pentylenetetrazole
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Receptors, GABA-A / drug effects
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Spectrophotometry, Infrared
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Anticonvulsants
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Convulsants
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Indicators and Reagents
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Oxadiazoles
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Receptors, GABA-A
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Pentylenetetrazole