Abstract
Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and freeze-thaw stability. Electrostatic interaction between negatively charged model drug aspirin and positively charged co-polymer plays the most important role in drug loading and in vitro release studies. Drug release exhibited a biphasic profile with an initial burst release followed by a prolonged slow release, which could be potentially useful for target and controlled drug delivery.
MeSH terms
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Acrylates / chemistry*
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Aspirin / chemistry
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Chemistry, Pharmaceutical / methods*
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Chlorides / chemistry
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Colloids / chemistry
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Drug Carriers / chemistry*
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Drug Stability
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Ferric Compounds / chemistry*
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Hydrogen-Ion Concentration
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Ions / chemistry
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Magnetics
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Microscopy, Electron, Transmission
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Nanocomposites / chemistry*
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Nanoparticles / chemistry
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Phosphates / chemistry
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Polymers / chemistry
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Sodium Chloride / chemistry
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Solubility
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Static Electricity
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Temperature
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Trimethyl Ammonium Compounds / chemistry
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Water / chemistry
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X-Ray Diffraction
Substances
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Acrylates
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Chlorides
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Colloids
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Drug Carriers
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Ferric Compounds
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Ions
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Phosphates
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Polymers
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Trimethyl Ammonium Compounds
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Water
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ferric oxide
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Sodium Chloride
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Aspirin