Good's syndrome in a patient with cytomegalovirus retinitis

David S P Yong; M K Tsang; Eric Y T Chan; Doris M W Tse

Good's syndrome in a patient with cytomegalovirus retinitis

Hong Kong Med J. 2008 Apr;14(2):142-4.

Authors

David S P Yong¹, M K Tsang, Eric Y T Chan, Doris M W Tse

Affiliation

¹ Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong.

PMID: 18382022

Abstract

Thymoma-related adult-onset immunodeficiency or Good's syndrome is an uncommon condition. This case, of a 50-year-old woman who was human immunodeficiency virus-negative and developed herpes zoster and severe cytomegalovirus retinitis 6 months after removal of a thymoma, is the first to be reported in Hong Kong. Immunological investigations revealed no B cells, hypogammaglobulinaemia, a low CD4 count, and a low CD4/CD8 ratio. We recommend that immunological investigations, including T-cell subsets, B cells, and quantitative immunoglobulins, should be part of the routine diagnostic evaluation of patients with thymoma and infections.

Publication types

Case Reports

MeSH terms

Agammaglobulinemia / diagnosis
Agammaglobulinemia / immunology
B-Lymphocytes / immunology
CD4 Lymphocyte Count
CD4-CD8 Ratio
Cytomegalovirus Retinitis / diagnosis*
Cytomegalovirus Retinitis / immunology
Diagnosis, Differential
Female
Herpes Zoster / diagnosis
Humans
Immunologic Deficiency Syndromes / diagnosis*
Immunologic Deficiency Syndromes / immunology
Middle Aged
Opportunistic Infections / diagnosis*
Opportunistic Infections / immunology
Postoperative Complications / diagnosis*
Postoperative Complications / immunology
Thymectomy*
Thymoma / immunology
Thymoma / surgery*
Thymus Neoplasms / immunology
Thymus Neoplasms / surgery*