MDCT angiography for detection of pulmonary emboli: comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL

Eur J Radiol. 2009 Jun;70(3):579-88. doi: 10.1016/j.ejrad.2008.01.058. Epub 2008 Apr 1.

Abstract

Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism.

Methods: Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n=40) or iodixanol 320 (n=40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation.

Results: There were no between-group differences (p>0.05) in demographics. Pulmonary artery attenuation was significantly (p<or=0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted.

Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Angiography / methods*
  • Contrast Media / administration & dosage
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Iopamidol / administration & dosage
  • Iopamidol / analogs & derivatives*
  • Male
  • Pulmonary Artery / diagnostic imaging
  • Pulmonary Embolism / diagnostic imaging*
  • Radiographic Image Enhancement / methods*
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*
  • Triiodobenzoic Acids* / administration & dosage

Substances

  • Contrast Media
  • Triiodobenzoic Acids
  • iomeprol
  • iodixanol
  • Iopamidol