Catalase-negative Staphylococcus aureus strain with point mutations in the katA gene

C Piau; J Jehan; R Leclercq; C Daurel

doi:10.1128/JCM.02300-07

Catalase-negative Staphylococcus aureus strain with point mutations in the katA gene

J Clin Microbiol. 2008 Jun;46(6):2060-1. doi: 10.1128/JCM.02300-07. Epub 2008 Apr 2.

Authors

C Piau¹, J Jehan, R Leclercq, C Daurel

Affiliation

¹ Service de Microbiologie, Université de Caen Basse-Normandie, CHU Côte de Nacre, 14033 Caen cedex, France.

Abstract

Methicillin-susceptible catalase-negative Staphylococcus aureus strain UCN61 was isolated from an arterial leg ulcer. The deduced sequence of the structural katA gene for the catalase was 99% identical to those of other S. aureus strains. Two mutations were identified in katA from S. aureus UCN61, including one leading to a substitution of key histidine 58 by a tyrosine.

Publication types

Case Reports

MeSH terms

Aged
Arterial Occlusive Diseases / complications
Bacterial Proteins / genetics*
Bacterial Proteins / metabolism
Catalase / genetics*
Catalase / metabolism
Female
Humans
Leg Ulcer / diagnosis
Leg Ulcer / microbiology*
Point Mutation*
Staphylococcal Infections / diagnosis
Staphylococcal Infections / microbiology*
Staphylococcus aureus / enzymology*
Staphylococcus aureus / genetics

Substances

Bacterial Proteins
Catalase