Abstract
Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)tyramine, cannabisin G and (+/-)-lyoniresinol. Of these, cannabisin G and (+/-)-lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anisoles / analysis
-
Anisoles / pharmacology*
-
Antioxidants / chemistry
-
Antioxidants / pharmacology*
-
Berberis / chemistry*
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Chemical Fractionation
-
Chromatography, High Pressure Liquid
-
Coumaric Acids / analysis
-
Coumaric Acids / pharmacology*
-
Cytoprotection
-
Free Radical Scavengers
-
Humans
-
Hydroxyl Radical
-
Naphthalenes / analysis
-
Naphthalenes / pharmacology*
-
Oxidative Stress / drug effects
-
Phenols / analysis
-
Phenols / pharmacology*
-
Phytotherapy
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology
-
Plant Roots / chemistry
Substances
-
Anisoles
-
Antioxidants
-
Coumaric Acids
-
Free Radical Scavengers
-
N-(4-hydroxy-beta-phenethyl)-4-hydroxycinnamide
-
Naphthalenes
-
Phenols
-
Plant Extracts
-
cannabisin G
-
lyoniresinol
-
Hydroxyl Radical